One wet Friday evening, Professor Andrew Martin solves the world's greatest mathematical riddle. Then he disappears. When he is found walking naked along the motorway, Professor Martin has changed. He now finds normal life pointless. His loving wife and teenage son seem repulsive to him. In fact, he hates everyone on the planet. Everyone except Newton. And he's a dog. Can a bit of Debussy and Emily Dickinson keep him from murder? And what can he possibly learn from life among the humans?